Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis

Neonates are at increased risk for bacterial sepsis. We established that the immune-suppressive cytokine interleukin-27 (IL-27) is elevated in neonatal mice. Similarly, human cord blood-derived macrophages express IL-27 genes and secrete more cytokine than macrophages from adults. In the present wor...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Seman, Brittany G., Vance, Jordan K., Rawson, Travis W., Witt, Michelle R., Huckaby, Annalisa B., Povroznik, Jessica M., Bradford, Shelby D., Barbier, Mariette, Robinson, Cory M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035946/
https://ncbi.nlm.nih.gov/pubmed/31818960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00828-19
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