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Major Histocompatibility Complex Class II-Restricted, CD4(+) T Cell-Dependent and -Independent Mechanisms Are Required for Vaccine-Induced Protective Immunity against Coxiella burnetii

To understand the role of major histocompatibility complex class I (MHC-I) and MHC-II in vaccine-mediated protection against Coxiella burnetii, we evaluated the protective efficacy of a formalin-inactivated C. burnetii Nine Mile phase I vaccine (PIV) in β(2)-microglobulin-deficient (B2m KO) and MHC-...

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Dettagli Bibliografici
Pubblicato in:Infect Immun
Autori principali: Ledbetter, Lindsey, Cherla, Rama, Chambers, Catherine, Zhang, Yan, Mitchell, William J., Zhang, Guoquan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035945/
https://ncbi.nlm.nih.gov/pubmed/31792078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00824-19
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