Pathways That Synthesize Phosphatidylethanolamine Impact Candida albicans Hyphal Length and Cell Wall Composition through Transcriptional and Posttranscriptional Mechanisms

Candida albicans is a leading cause of systemic bloodstream infections, and synthesis of the phospholipid phosphatidylethanolamine (PE) is required for virulence. The psd1Δ/Δ psd2Δ/Δ mutant, which cannot synthesize PE by the cytidine diphosphate diacylglycerol (CDP-DAG) pathway, is avirulent in the...

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Publicado en:Infect Immun
Autores principales: Tams, Robert N., Wagner, Andrew S., Jackson, Joseph W., Gann, Eric R., Sparer, Timothy E., Reynolds, Todd B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035933/
https://ncbi.nlm.nih.gov/pubmed/31792076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00480-19
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