Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of De Novo Phosphatidylethanolamine Synthesis

Candida albicans mutants for phosphatidylserine (PS) synthase (cho1ΔΔ) and PS decarboxylase (psd1ΔΔ psd2ΔΔ) are compromised for virulence in mouse models of systemic infection and oropharyngeal candidiasis (OPC). Both of these enzymes are necessary to synthesize phosphatidylethanolamine (PE) by the...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Davis, Sarah E., Tams, Robert N., Solis, Norma V., Wagner, Andrew S., Chen, Tian, Jackson, Joseph W., Hasim, Sahar, Montedonico, Anthony E., Dinsmore, Justin, Sparer, Timothy E., Filler, Scott G., Reynolds, Todd B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056879/
https://ncbi.nlm.nih.gov/pubmed/29866908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00815-17
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