Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of De Novo Phosphatidylethanolamine Synthesis

Candida albicans mutants for phosphatidylserine (PS) synthase (cho1ΔΔ) and PS decarboxylase (psd1ΔΔ psd2ΔΔ) are compromised for virulence in mouse models of systemic infection and oropharyngeal candidiasis (OPC). Both of these enzymes are necessary to synthesize phosphatidylethanolamine (PE) by the...

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Опубликовано в: :Infect Immun
Главные авторы: Davis, Sarah E., Tams, Robert N., Solis, Norma V., Wagner, Andrew S., Chen, Tian, Jackson, Joseph W., Hasim, Sahar, Montedonico, Anthony E., Dinsmore, Justin, Sparer, Timothy E., Filler, Scott G., Reynolds, Todd B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
Предметы:
Fungal and Parasitic Infections
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056879/
https://ncbi.nlm.nih.gov/pubmed/29866908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00815-17
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