Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of De Novo Phosphatidylethanolamine Synthesis

Candida albicans mutants for phosphatidylserine (PS) synthase (cho1ΔΔ) and PS decarboxylase (psd1ΔΔ psd2ΔΔ) are compromised for virulence in mouse models of systemic infection and oropharyngeal candidiasis (OPC). Both of these enzymes are necessary to synthesize phosphatidylethanolamine (PE) by the...

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Vydáno v:Infect Immun
Hlavní autoři: Davis, Sarah E., Tams, Robert N., Solis, Norma V., Wagner, Andrew S., Chen, Tian, Jackson, Joseph W., Hasim, Sahar, Montedonico, Anthony E., Dinsmore, Justin, Sparer, Timothy E., Filler, Scott G., Reynolds, Todd B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Fungal and Parasitic Infections
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056879/
https://ncbi.nlm.nih.gov/pubmed/29866908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00815-17
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