Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications

BACKGROUND: New therapies are urgently needed in melanoma particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. METHODS: Drug screening, IC50 determinations as well as synergy assays were detected by the MTT assay. Apoptosis using Annexin V and 7AAD staining wa...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Liu, Wei, Stachura, Paweł, Xu, Haifeng C., Umesh Ganesh, Nikkitha, Cox, Fiona, Wang, Ruifeng, Lang, Karl S., Gopalakrishnan, Jay, Häussinger, Dieter, Homey, Bernhard, Lang, Philipp A., Pandyra, Aleksandra A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035645/
https://ncbi.nlm.nih.gov/pubmed/32085796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-1539-7
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