Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy

The chaperone protein SmgGDS promotes cell-cycle progression and tumorigenesis in human breast and nonsmall cell lung cancer. Splice variants of SmgGDS, named SmgGDS-607 and SmgGDS-558, facilitate the activation of oncogenic members of the Ras and Rho families of small GTPases through membrane traff...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Brandt, Anthony C., McNally, Lisa, Lorimer, Ellen L., Unger, Bethany, Koehn, Olivia J., Suazo, Kiall F., Rein, Lisa, Szabo, Aniko, Tsaih, Shirng-Wern, Distefano, Mark D., Flister, Michael J., Rigo, Frank, McNally, Mark T., Williams, Carol L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035473/
https://ncbi.nlm.nih.gov/pubmed/32019878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914153117
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