Laminar flow inhibits the Hippo/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis

Atherosclerosis is a multifactorial disease of the vasculature, and shear stress is a crucial regulator of its process. Disturbed flow promotes atherosclerotic effects, while laminar flow has a protective action on the endothelium. Hippo/YAP is a major cascade that senses various mechanical cues and...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Yuan, Ping, Hu, Qiongying, He, Xuemei, Long, Yang, Song, Xueqin, Wu, Fei, He, Yanzheng, Zhou, Xiangyu
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035362/
https://ncbi.nlm.nih.gov/pubmed/32081881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2343-1
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