SIRT1 inhibition promotes atherosclerosis through impaired autophagy

SIRT1, a highly conserved NAD(+)-dependent protein deacetylase, plays a pivotal role in the pathogenesis and therapy of atherosclerosis (AS). The aim of this study is to investigate the potential effects of SIRT1 on AS in ApoE(–/–) mice and the underlying mechanisms of autophagy in an ox-LDL-stimula...

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Vydáno v:Oncotarget
Hlavní autoři: Yang, Xiaofeng, Wei, Jingyuan, He, Yanhao, Jing, Ting, Li, Yanxiang, Xiao, Yunfang, Wang, Bo, Wang, Weirong, Zhang, Jiye, Lin, Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584260/
https://ncbi.nlm.nih.gov/pubmed/28881659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17691
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