SIRT5‐mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

Lactate dehydrogenase B (LDHB) is a glycolytic enzyme that catalyses the conversion of lactate and NAD (+) to pyruvate, NADH and H(+). Protons (H(+)) generated by LDHB promote lysosomal acidification and autophagy in cancer, but how this role is regulated has not been defined. In this study, we iden...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Oncol
Egile Nagusiak: Shi, Liang, Yan, Hui, An, Shuxian, Shen, Mengqin, Jia, Wenzhi, Zhang, Ruixue, Zhao, Li, Huang, Gang, Liu, Jianjun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360364/
https://ncbi.nlm.nih.gov/pubmed/30443978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12408
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