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The structural basis for cohesin-CTCF anchored loops
Cohesin catalyzes folding of the genome into loops that are anchored by CTCF(1). The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within the CTCF N-terminus interacts with the SA2-SCC1 subunits of cohesin. A 2.6Å crystal struct...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035113/ https://ncbi.nlm.nih.gov/pubmed/31905366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1910-z |
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