Phase 2 Study of Radiation Therapy Plus Low Dose Temozolomide Followed by Temozolomide and Irinotecan for Glioblastoma: NRG Oncology RTOG Trial 0420

PURPOSE: Evaluate the toxicity and efficacy of adjuvant temozolomide (TMZ) and irinotecan (CPT-11) for 12 months following concurrent chemo-radiation in newly diagnosed glioblastoma (GBM). METHODS: Trial RTOG 04-20, a single arm, multi-institutional phase 2 trial was designed to determine the effica...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Lieberman, Frank S, Wang, Meihua, Robins, H Ian, Tsien, Christina I, Curran, Walter J, Werner-Wasik, Maria, Smith, Ryan P, Schultz, Christopher, Hartford, Alan C, Zhang, Peixin, Mehta, Minesh P
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034757/
https://ncbi.nlm.nih.gov/pubmed/30496882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2018.11.008
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