HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

The molecular mechanisms of β-cell compensation to metabolic stress are poorly understood. We previously observed that nutrient-induced β-cell proliferation in rats is dependent on epidermal growth factor receptor (EGFR) signaling. The aim of this study was to determine the role of the EGFR ligand h...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Maachi, Hasna, Fergusson, Grace, Ethier, Melanie, Brill, Gabriel N., Katz, Liora S., Honig, Lee B., Metukuri, Mallikarjuna R., Scott, Donald K., Ghislain, Julien, Poitout, Vincent
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2020
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034189/
https://ncbi.nlm.nih.gov/pubmed/31882563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0643
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