C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is available about structure-activity relationship (SAR) aro...

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Bibliographic Details
Published in:J Enzyme Inhib Med Chem
Main Authors: Felicetti, Tommaso, Mangiaterra, Gianmarco, Cannalire, Rolando, Cedraro, Nicholas, Pietrella, Donatella, Astolfi, Andrea, Massari, Serena, Tabarrini, Oriana, Manfroni, Giuseppe, Barreca, Maria Letizia, Cecchetti, Violetta, Biavasco, Francesca, Sabatini, Stefano
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2020
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Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034129/
https://ncbi.nlm.nih.gov/pubmed/31992093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1719083
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