Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase

[Image: see text] Treatment of dengue virus (DENV) and other flavivirus infections is an unmet medical need. The highly conserved flaviviral NS5 RNA-dependent RNA polymerase (RdRp) is an attractive antiviral target that interacts with NS3 and viral RNA within the replication complex assembly. Bioche...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Cannalire, Rolando, Ki Chan, Kitti Wing, Burali, Maria Sole, Gwee, Chin Piaw, Wang, Sai, Astolfi, Andrea, Massari, Serena, Sabatini, Stefano, Tabarrini, Oriana, Mastrangelo, Eloise, Barreca, Maria Letizia, Cecchetti, Violetta, Vasudevan, Subhash G., Manfroni, Giuseppe
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236247/
https://ncbi.nlm.nih.gov/pubmed/32435384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00619
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