C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is available about structure-activity relationship (SAR) aro...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Felicetti, Tommaso, Mangiaterra, Gianmarco, Cannalire, Rolando, Cedraro, Nicholas, Pietrella, Donatella, Astolfi, Andrea, Massari, Serena, Tabarrini, Oriana, Manfroni, Giuseppe, Barreca, Maria Letizia, Cecchetti, Violetta, Biavasco, Francesca, Sabatini, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034129/
https://ncbi.nlm.nih.gov/pubmed/31992093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1719083
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