The Methyl-CpG-Binding Protein Mbd2 Regulates Susceptibility to Experimental Colitis via Control of CD11c(+) Cells and Colonic Epithelium

Methyl-CpG-binding domain-2 (Mbd2) acts as an epigenetic regulator of gene expression, by linking DNA methylation to repressive chromatin structure. Although Mbd2 is widely expressed in gastrointestinal immune cells and is implicated in regulating intestinal cancer, anti-helminth responses and colon...

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Publicado en:Front Immunol
Autores principales: Jones, Gareth-Rhys, Brown, Sheila L., Phythian-Adams, Alexander T., Ivens, Alasdair C., Cook, Peter C., MacDonald, Andrew S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033935/
https://ncbi.nlm.nih.gov/pubmed/32117307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00183
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