The Methyl-CpG-Binding Protein Mbd2 Regulates Susceptibility to Experimental Colitis via Control of CD11c(+) Cells and Colonic Epithelium

Methyl-CpG-binding domain-2 (Mbd2) acts as an epigenetic regulator of gene expression, by linking DNA methylation to repressive chromatin structure. Although Mbd2 is widely expressed in gastrointestinal immune cells and is implicated in regulating intestinal cancer, anti-helminth responses and colon...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jones, Gareth-Rhys, Brown, Sheila L., Phythian-Adams, Alexander T., Ivens, Alasdair C., Cook, Peter C., MacDonald, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033935/
https://ncbi.nlm.nih.gov/pubmed/32117307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00183
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