Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT(4) receptors activities for the treatment of Alzheimer’s disease

A rigidification strategy was applied to the preclinical candidate donecopride, an acetylcholinesterase inhibitor possessing 5-HT(4)R agonist activity. Inspired by promising bioactive benzisoxazole compounds, we have conducted a pharmacomodulation study to generate a novel series of multitarget dire...

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Published in:Sci Rep
Main Authors: Lalut, Julien, Payan, Hugo, Davis, Audrey, Lecoutey, Cédric, Legay, Rémi, Sopkova-de Oliveira Santos, Jana, Claeysen, Sylvie, Dallemagne, Patrick, Rochais, Christophe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033111/
https://ncbi.nlm.nih.gov/pubmed/32080261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59805-7
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