BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

BRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1 associate with poor prognosis in human prostate cancer. In vitro studies in human prostate cancer cell lines demonstrated that transient over...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Loveridge, Carolyn J., Slater, Sarah, Campbell, Kirsteen J., Nam, Noor A., Knight, John, Ahmad, Imran, Hedley, Ann, Lilla, Sergio, Repiscak, Peter, Patel, Rachana, Salji, Mark, Fleming, Janis, Mitchell, Louise, Nixon, Colin, Strathdee, Douglas, Neilson, Matthew, Ntala, Chara, Bryson, Sheila, Zanivan, Sara, Edwards, Joanne, Robson, Craig N., Goodyear, Carl S., Blyth, Karen, Leung, Hing Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033044/
https://ncbi.nlm.nih.gov/pubmed/31740786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1106-x
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