Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis

Prostate cancer (PCa) does not appear to respond to immune checkpoint therapies where T cell infiltration may be a key limiting factor. Here we report evidence that ablating the growth regulatory kinase Erk5 can increase T cell infiltration in an established Pten-deficient mouse model of human PCa....

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Veröffentlicht in:Cancer Res
Hauptverfasser: Loveridge, Carolyn J., Mui, Ernest J., Patel, Rachana, Tan, Ee Hong, Ahmad, Imran, Welsh, Michelle, Galbraith, Julie, Hedley, Ann, Nixon, Colin, Blyth, Karen, Sansom, Owen, Leung, Hing Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474317/
https://ncbi.nlm.nih.gov/pubmed/28515147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2565
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