Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cells. Overexpression and mislocalization of CENP-A ha...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Au, Wei-Chun, Zhang, Tianyi, Mishra, Prashant K., Eisenstatt, Jessica R., Walker, Robert L., Ocampo, Josefina, Dawson, Anthony, Warren, Jack, Costanzo, Michael, Baryshnikova, Anastasia, Flick, Karin, Clark, David J., Meltzer, Paul S., Baker, Richard E., Myers, Chad, Boone, Charles, Kaiser, Peter, Basrai, Munira A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032732/
https://ncbi.nlm.nih.gov/pubmed/32032354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008597
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