Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cells. Overexpression and mislocalization of CENP-A ha...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Au, Wei-Chun, Zhang, Tianyi, Mishra, Prashant K., Eisenstatt, Jessica R., Walker, Robert L., Ocampo, Josefina, Dawson, Anthony, Warren, Jack, Costanzo, Michael, Baryshnikova, Anastasia, Flick, Karin, Clark, David J., Meltzer, Paul S., Baker, Richard E., Myers, Chad, Boone, Charles, Kaiser, Peter, Basrai, Munira A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032732/
https://ncbi.nlm.nih.gov/pubmed/32032354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008597
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi