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Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis

Platelet inositol hexakisphosphate kinase 1 (IP6K1) has been shown to control systemic inflammation. Herein, we examined if platelets and IP6K1 regulate pancreatic tissue injury via formation of NETs in experimental models of acute pancreatitis (AP) in mice. By use of electron microscopy abundant NE...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Madhi, Raed, Rahman, Milladur, Taha, Dler, Linders, Johan, Merza, Mohammed, Wang, Yongzhi, Mörgelin, Matthias, Thorlacius, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032015/
https://ncbi.nlm.nih.gov/pubmed/31593553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129270
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