A proof‐of‐concept study on the effects of low total cfDNA content and solutions to increase the NIPT trisomy 21 detection rate

BACKGROUND: Non‐invasive prenatal testing (NIPT) is routinely used in clinical practice for fetal trisomy screening, but low total cfDNA content and low fetal fraction (LFF) are two factors that affect the detection rate. Samples with low total cfDNA or LFF usually end up with “no‐call” results, fol...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Lab Anal
Hauptverfasser: Du, Yang, Chen, Ailing, Yang, Rui, Zhou, Tao, Zhou, Qin, Yang, Lan, Wang, Juan, Hong, Yan, Chen, Chen, Wan, Qian, Yang, Lin, Chen, Ying
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031630/
https://ncbi.nlm.nih.gov/pubmed/31568605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcla.23035
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