Could Digital PCR Be an Alternative as a Non-Invasive Prenatal Test for Trisomy 21: A Proof of Concept Study

OBJECTIVE: NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions needed to meet statistical requirements, preventing clinical application. Here, we designed an octoplex droplet digital PCR (ddPCR) assay which allows increasing the number of available targets...

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Bibliographic Details
Published in:PLoS One
Main Authors: El Khattabi, Laïla Allach, Rouillac-Le Sciellour, Christelle, Le Tessier, Dominique, Luscan, Armelle, Coustier, Audrey, Porcher, Raphael, Bhouri, Rakia, Nectoux, Juliette, Sérazin, Valérie, Quibel, Thibaut, Mandelbrot, Laurent, Tsatsaris, Vassilis, Vialard, François, Dupont, Jean-Michel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864235/
https://ncbi.nlm.nih.gov/pubmed/27167625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155009
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