A randomized, 3-arm, neoadjuvant, phase 2 study comparing docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP), TCbHP followed by trastuzumab emtansine and pertuzumab (T-DM1+P), and T-DM1+P in HER2-positive primary breast cancer

PURPOSE: The standard of care in the neoadjuvant setting for human epidermal growth factor receptor 2 (HER2)-positive breast cancer is dual HER2-targeted therapy. However, a need to minimize treatment-related toxicity and improve pathological complete response (pCR) rates, particularly in luminal HE...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Masuda, Norikazu, Ohtani, Shoichiro, Takano, Toshimi, Inoue, Kenichi, Suzuki, Eiji, Nakamura, Rikiya, Bando, Hiroko, Ito, Yoshinori, Ishida, Kazushige, Yamanaka, Takashi, Kuroi, Katsumasa, Yasojima, Hiroyuki, Kasai, Hiroi, Takasuka, Tsuyoshi, Sakurai, Takaki, Kataoka, Tatsuki R., Morita, Satoshi, Ohno, Shinji, Toi, Masakazu
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Clinical Trial
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031180/
https://ncbi.nlm.nih.gov/pubmed/31953696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-020-05524-6
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