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Triplicate PCR reactions for 16S rRNA gene amplicon sequencing are unnecessary

Conventional wisdom holds that PCR amplification for sequencing should employ pooled replicate reactions to reduce bias due to jackpot effects and chimera formation. However, modern amplicon data analysis employs methods that may be less sensitive to such artifacts. Here we directly compare results...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biotechniques
Hauptverfasser: Marotz, Clarisse, Sharma, Anukriti, Humphrey, Greg, Gottel, Neil, Daum, Christopher, Gilbert, Jack A, Eloe-Fadrosh, Emiley, Knight, Rob
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030937/
https://ncbi.nlm.nih.gov/pubmed/31124709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2144/btn-2018-0192
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