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Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable

Posttransplantation diabetes mellitus (PTDM) is a common and significant complication related to immunosuppressive agents required to prevent organ or cell transplant rejection. To elucidate the effects of 2 commonly used agents, the calcineurin inhibitor tacrolimus (TAC) and the mTOR inhibitor siro...

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Опубликовано в: :JCI Insight
Главные авторы: Dai, Chunhua, Walker, John T., Shostak, Alena, Padgett, Ana, Spears, Erick, Wisniewski, Scott, Poffenberger, Greg, Aramandla, Radhika, Dean, E. Danielle, Prasad, Nripesh, Levy, Shawn E., Greiner, Dale L., Shultz, Leonard D., Bottino, Rita, Powers, Alvin C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030815/
https://ncbi.nlm.nih.gov/pubmed/31941840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130770
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