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St. John’s Wort Influence on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics and Clinical Effects. A Randomized Clinical Trial.

BACKGROUND: Patients often use complementary and alternative herbal medicines; hence potential exists for adverse herb-drug interactions. Fentanyl is metabolized by hepatic CYP3A4 and considered transported by blood-brain barrier P-glycoprotein. Both disposition processes could be upregulated by the...

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Bibliografische gegevens
Gepubliceerd in:Anesthesiology
Hoofdauteurs: Loughren, Michael J., Kharasch, Evan D., Kelton-Rehkopf, Megan C., Syrjala, Karen L, Shen, Danny D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029805/
https://ncbi.nlm.nih.gov/pubmed/31794512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003065
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