Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection

BACKGROUND: Chagas disease, which is caused by the protozoan Trypanosoma cruzi, is endemic to Latin America and mainly affects low-income populations. Chemotherapy is based on two nitrocompounds, but their reduced efficacy encourages the continuous search for alternative drugs. Our group has charact...

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Publicado en:Mem Inst Oswaldo Cruz
Autores principales: Cascabulho, Cynthia M, Meuser-Batista, Marcelo, de Moura, Kelly Cristina G, Pinto, Maria do Carmo, Duque, Thabata Lopes Alberto, Demarque, Kelly C, Guimarães, Ana Carolina Ramos, Manso, Pedro Paulo de Abreu, Pelajo-Machado, Marcelo, Oliveira, Gabriel M, Castro, Solange L De, Menna-Barreto, Rubem FS
Formato: Artigo
Lenguaje:Inglês
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029714/
https://ncbi.nlm.nih.gov/pubmed/32074167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760190389
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