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Synthesis and biological evaluation of N-alkyl naphthoimidazoles derived from β-lapachone against Trypanosoma cruzi bloodstream trypomastigotes
The QSAR study of 34 2-aryl-naphthoimidazoles screened so far revealed that σ(i) is the most important factor for their lytic activity on the bloodstream trypomastigote forms of T. cruzi, the etiologic agent of Chagas disease. Based on this result, 16 new N-alkyl-naphthoimidazoles derived from 6,6-d...
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| Publicat a: | Medchemcomm |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071937/ https://ncbi.nlm.nih.gov/pubmed/30108809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00069c |
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