A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that Activin A regulates NANOG

BACKGROUND: NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a conserved pluripotency-associated factor. However, pig NANOG reporter PSCs have...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Xu, Junjun, Zheng, Zheng, Du, Xuguang, Shi, Bingbo, Wang, Jichang, Gao, Dengfeng, Zhu, Qianqian, Chen, Xinze, Han, Jianyong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029561/
https://ncbi.nlm.nih.gov/pubmed/32070424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-1588-z
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