Class A GPCRs harness the energy of membrane potential to increase their sensitivity and selectivity

The human genome contains about 700 genes of G protein-coupled receptors (GPCRs) of class A; these seven-helical membrane proteins are the targets of almost half of all known drugs. In the middle of the helix bundle, crystal structures revealed a highly conserved sodium-binding site, which is connec...

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Bibliographic Details
Published in:Biochim Biophys Acta Biomembr
Main Authors: Shalaeva, Daria N., Cherepanov, Dmitry A., Galperin, Michael Y., Vriend, Gert, Mulkidjanian, Armen Y.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029430/
https://ncbi.nlm.nih.gov/pubmed/31449800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2019.183051
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