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Evolution of cation binding in the active sites of P-loop nucleoside triphosphatases in relation to the basic catalytic mechanism

The ubiquitous P-loop fold nucleoside triphosphatases (NTPases) are typically activated by an arginine or lysine ‘finger’. Some of the apparently ancestral NTPases are, instead, activated by potassium ions. To clarify the activation mechanism, we combined comparative structure analysis with molecula...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shalaeva, Daria N, Cherepanov, Dmitry A, Galperin, Michael Y, Golovin, Andrey V, Mulkidjanian, Armen Y
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310460/
https://ncbi.nlm.nih.gov/pubmed/30526846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37373
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