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Class A GPCRs harness the energy of membrane potential to increase their sensitivity and selectivity
The human genome contains about 700 genes of G protein-coupled receptors (GPCRs) of class A; these seven-helical membrane proteins are the targets of almost half of all known drugs. In the middle of the helix bundle, crystal structures revealed a highly conserved sodium-binding site, which is connec...
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| Publicado no: | Biochim Biophys Acta Biomembr |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7029430/ https://ncbi.nlm.nih.gov/pubmed/31449800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2019.183051 |
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