Mild innate immune activation overrides efficient nanoparticle-mediated RNA delivery

Clinical mRNA delivery remains challenging, in large part because how physiology alters delivery in vivo remains underexplored. For example, mRNA delivered by lipid nanoparticles (LNPs) is being considered to treat inflammation, but whether inflammation changes delivery remains understudied. Relatio...

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Detalhes bibliográficos
Publicado no:Adv Mater
Main Authors: Lokugamage, Melissa P., Gan, Zubao, Zurla, Chiara, Levin, Joel, Islam, Fatima Z., Kalathoor, Sujay, Sato, Manaka, Sago, Cory D., Santangelo, Philip J., Dahlman, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029413/
https://ncbi.nlm.nih.gov/pubmed/31743531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201904905
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