Mild innate immune activation overrides efficient nanoparticle-mediated RNA delivery

Clinical mRNA delivery remains challenging, in large part because how physiology alters delivery in vivo remains underexplored. For example, mRNA delivered by lipid nanoparticles (LNPs) is being considered to treat inflammation, but whether inflammation changes delivery remains understudied. Relatio...

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Dades bibliogràfiques
Publicat a:Adv Mater
Autors principals: Lokugamage, Melissa P., Gan, Zubao, Zurla, Chiara, Levin, Joel, Islam, Fatima Z., Kalathoor, Sujay, Sato, Manaka, Sago, Cory D., Santangelo, Philip J., Dahlman, James E.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029413/
https://ncbi.nlm.nih.gov/pubmed/31743531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201904905
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