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Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands
T cells help regulate immunity, which makes them an important target for RNA therapies. While nanoparticles carrying RNA have been directed to T cells in vivo using protein- and aptamer-based targeting ligands, systemic delivery to T cells without targeting ligands remains challenging. Given that T...
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| Publicado no: | Adv Mater |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6819129/ https://ncbi.nlm.nih.gov/pubmed/31465135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201902251 |
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