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Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands
Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non‐hepatocyte delivery at clinical doses remains difficult. We noted that LNPs have historically been...
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| Izdano u: | Bioeng Transl Med |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley & Sons, Inc.
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7974401/ https://ncbi.nlm.nih.gov/pubmed/33758781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10161 |
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