Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

Intrinsic malignant brain tumors, such as glioblastomas are frequently resistant to immune checkpoint blockade (ICB) with few hypermutated glioblastomas showing response. Modeling patient-individual resistance is challenging due to the lack of predictive biomarkers and limited accessibility of tissu...

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Publicado no:Nat Commun
Main Authors: Aslan, Katrin, Turco, Verena, Blobner, Jens, Sonner, Jana K., Liuzzi, Anna Rita, Núñez, Nicolás Gonzalo, De Feo, Donatella, Kickingereder, Philipp, Fischer, Manuel, Green, Ed, Sadik, Ahmed, Friedrich, Mirco, Sanghvi, Khwab, Kilian, Michael, Cichon, Frederik, Wolf, Lara, Jähne, Kristine, von Landenberg, Anna, Bunse, Lukas, Sahm, Felix, Schrimpf, Daniel, Meyer, Jochen, Alexander, Allen, Brugnara, Gianluca, Röth, Ralph, Pfleiderer, Kira, Niesler, Beate, von Deimling, Andreas, Opitz, Christiane, Breckwoldt, Michael O., Heiland, Sabine, Bendszus, Martin, Wick, Wolfgang, Becher, Burkhard, Platten, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028933/
https://ncbi.nlm.nih.gov/pubmed/32071302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14642-0
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