Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

Intrinsic malignant brain tumors, such as glioblastomas are frequently resistant to immune checkpoint blockade (ICB) with few hypermutated glioblastomas showing response. Modeling patient-individual resistance is challenging due to the lack of predictive biomarkers and limited accessibility of tissu...

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Pubblicato in:Nat Commun
Autori principali: Aslan, Katrin, Turco, Verena, Blobner, Jens, Sonner, Jana K., Liuzzi, Anna Rita, Núñez, Nicolás Gonzalo, De Feo, Donatella, Kickingereder, Philipp, Fischer, Manuel, Green, Ed, Sadik, Ahmed, Friedrich, Mirco, Sanghvi, Khwab, Kilian, Michael, Cichon, Frederik, Wolf, Lara, Jähne, Kristine, von Landenberg, Anna, Bunse, Lukas, Sahm, Felix, Schrimpf, Daniel, Meyer, Jochen, Alexander, Allen, Brugnara, Gianluca, Röth, Ralph, Pfleiderer, Kira, Niesler, Beate, von Deimling, Andreas, Opitz, Christiane, Breckwoldt, Michael O., Heiland, Sabine, Bendszus, Martin, Wick, Wolfgang, Becher, Burkhard, Platten, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028933/
https://ncbi.nlm.nih.gov/pubmed/32071302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14642-0
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