CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high‐fat diet‐induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway

CTRP9 has been reported to regulate lipid metabolism and exert cardioprotective effects, yet its role in high‐fat diet (HFD)‐induced cardiac lipotoxicity and the underlying mechanisms remain unclear. In the current study, we established HFD‐induced obesity model in wild‐type (WT) or CTRP9 knockout (...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Zuo, Anju, Zhao, Xiaoyu, Li, Tingting, Li, Jun, Lei, Shengyun, Chen, Jiying, Xu, Dan, Song, Chengxiang, Liu, Tianjiao, Li, Cuigang, Guo, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028852/
https://ncbi.nlm.nih.gov/pubmed/31930700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14982
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