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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. The hypertrophic process is mediated, in part, by small G proteins of the Rho family. We hypothesized that statins, inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, inhibit cardiac hypertrophy by blocking Rho isoprenyl...

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Publicado no:J Clin Invest
Principais autores: Takemoto, Masao, Node, Koichi, Nakagami, Hironori, Liao, Yulin, Grimm, Michael, Takemoto, Yaeko, Kitakaze, Masafumi, Liao, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209420/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11714734/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13350
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