Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. The hypertrophic process is mediated, in part, by small G proteins of the Rho family. We hypothesized that statins, inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, inhibit cardiac hypertrophy by blocking Rho isoprenyl...

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Εκδόθηκε σε:	J Clin Invest
Κύριοι συγγραφείς:	Takemoto, Masao, Node, Koichi, Nakagami, Hironori, Liao, Yulin, Grimm, Michael, Takemoto, Yaeko, Kitakaze, Masafumi, Liao, James K.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Clinical Investigation 2001
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11714734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13350
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