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PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models
PT-112 is a novel platinum-pyrophosphate conjugate under clinical development for cancer therapy. PT-112 mediates cytostatic and cytotoxic effects against a variety of human and mouse cancer cell lines in vitro. The cytotoxic response to PT-112 is associated with the emission of danger signals under...
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| Publié dans: | Oncoimmunology |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7028345/ https://ncbi.nlm.nih.gov/pubmed/32117585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1721810 |
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