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Exposure–Response Analyses for Upadacitinib Efficacy and Safety in the Crohn's Disease CELEST Study and Bridging to the Extended‐Release Formulation

Upadacitinib plasma concentrations, efficacy, and safety data from 216 subjects with moderate‐to‐severe active Crohn's disease (CD) from the 16‐week induction period of the CELEST study were analyzed to characterize upadacitinib exposure–response relationships in CD. Subjects in CELEST received...

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Publicat a:Clin Pharmacol Ther
Autors principals: Mohamed, Mohamed‐Eslam F., Klünder, Ben, Lacerda, Ana P., Othman, Ahmed A.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027977/
https://ncbi.nlm.nih.gov/pubmed/31594037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1668
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