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Population Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I and II Clinical Trials

BACKGROUND AND OBJECTIVES: Upadacitinib is a janus kinase (JAK) 1 inhibitor being developed for the treatment of rheumatoid arthritis (RA) and other inflammatory diseases. This work characterized upadacitinib population pharmacokinetics in healthy subjects and RA patients and the effects of covariat...

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Bibliografske podrobnosti
izdano v:Clin Pharmacokinet
Main Authors: Klünder, Ben, Mohamed, Mohamed-Eslam F., Othman, Ahmed A.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028884/
https://ncbi.nlm.nih.gov/pubmed/29076110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0605-6
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