Aflatoxin-Guanine DNA Adducts and Oxidatively Induced DNA Damage in Aflatoxin-Treated Mice in Vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope Dilution

Dietary exposure to aflatoxin B(1) (AFB(1)) is a significant contributor to the incidence of hepatocellular carcinomas globally. AFB(1) exposure leads to the formation of AFB(1)-N(7)-guanine (AFB(1)-N(7)-Gua) and two diastereomers of the imidazole ring-opened 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dih...

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發表在:Chem Res Toxicol
Main Authors: Coskun, Erdem, Jaruga, Pawel, Vartanian, Vladimir, Erdem, Onur, Egner, Patricia A., Groopman, John D., Lloyd, R. Stephen, Dizdaroglu, Miral
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027973/
https://ncbi.nlm.nih.gov/pubmed/30525498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00202
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