Enhancement of β-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing Na(V)1.5 expression in mice

BACKGROUND: β-catenin/T-cell factor 4 (TCF4) signaling is enhanced in ischemic heart disease in which ventricular tachycardia/fibrillation (VT/VF) occurs frequently. How this signaling links to arrhythmogenesis remains unclear. OBJECTIVE: To investigate the role of β-catenin gain of function in the...

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Detalhes bibliográficos
Publicado no:Heart Rhythm
Main Authors: Huo, Rong, Hu, Chaowei, Zhao, Limei, Sun, Lihua, Wang, Ning, Lu, Yan, Ye, Bo, Deb, Arjun, Li, Faqian, Xu, Haodong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027965/
https://ncbi.nlm.nih.gov/pubmed/31125668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2019.05.015
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